bK-IMP: mechanism of action and effects

When bK-IMP was applied to individual neurons by the of microiono-phoresis and pneumomicroinjection methods, it was found that it exerts a direct influence on most brain sensorimotor cortex neurons of awake animals, causing both inhibitory and excitatory reactions. bK-IMP has a pronounced ability to improve learning and memory processes, has a clear antiamnestic effect, eliminating memory impairments caused by various influences. In a recent experiment it was shown that bK-IMP effectively eliminates the conditioned passive avoidance reflex amnesia in rats caused by such severe effects as conducting maximum electric shock immediately after training, the scololamine cholinolytics introduction or after the deprivation of the paradoxical sleep phase. In terms of antiamnestic effects, bK-IMP isn’t inferior, and in some cases, superior to the activity and depth of effect, such nootropic drugs as piracetam, pyritinol, meclofenoxate, clerelial, pantogam, picamilon, sodium oxybutyrate. Along with the anti-amnestic effect, bK-IMP promotes the preservation of a memorable trace and counteracts the process of acquired skills and reflexes extinction.
The positive restorative effect of bK-IMP has on the impaired cognitive functions arising from natural aging and in the experimental models of Alzheimer’s and Parkinson’s diseases. Along with the learning and memory processes improvement in old animals, certain manifestations of neurologic deficits are eliminated under the bK-IMP influence, emotional status is restored, the cholesterol level, low-density lipoproteins, triglycerides, and lipofuscin is reduced to normal.
The positive influence mechanism of bK-IMP on cognitive functions is also related to its membrane-protective and antioxidant action. According to the synapse-membrane memory organization, the decisive role in fixing information in the central nervous system belongs to conformational displacements of protein macromolecules in the synapse region. bK-IMP, having a pronounced effect on the physicochemical properties of the membrane and causing its structural and functional rearrangements, increases the biological membrane functional activity and, thereby, promotes the formation of stable conformational changes in the protein macromolecules of synaptic membranes, the formation of interconnected systems of neuron membrane complexes, resulting in synaptic processes activation and cognitive functions improvement. Another important feature is the ability of bK-IMP to alter the phospholipid composition of the outer membrane of the brain synaptosomes; for memory processes, an increase in the phosphatidylserine content, which affects the activity of the potassium and calcium phase and phosphotidylinositol, which contributes to the acetylcholine receptor for acetylcholine affinity, is particularly important. In addition, the bK-IMP ability has been shown to interfere with the atheroarteriosclerosis development.
bK-IMP also has a pronounced anxiolytic effect, i.e. ability to eliminate fear, anxiety, stress, anxiety. In an experiment using the collision technique in rats, bK-IMP has a pronounced anxiolytic activity, increasing the number of punishable water withdrawals. It has a similar activity to diazepam, but unlike diazepam after bK-IMP, the response to stimulating test stimuli on the Brody-Nauta scale doesn’t deteriorate and there are no side effects in the sedation and muscle relaxation form.
bK-IMP influences various stress situations types, for example, under environment novelty stress, with anxiety and fear caused by negative influences previously received in these conditions, under the stress of pain expectation, in situations of discrepancy between the desired and the actual. An realization mechanism analysis of the bK-IMP anxiolytic effect showed that bK-IMP doesn’t have the ability to bind to benzodiazepine and GABA receptors, however, it has the ability to enhance the binding of labeled diazepam to benzodiazepine receptors. Thus, without direct affinity for benzodiazepine and GABA receptors, bK-IMP exerts a modifying effect on them, enhancing their ability to bind. In the light of current ideas about new type substances that aren’t related to direct receptor agonists, the bK-IMP effect can be represented as the modulator effect, an allosteric potentiating ligand receptor, and an ion channels activator by the membrane-receptor interaction mechanism. The anti-stress, anxiolytic effect is supplemented by the unique bK-IMP ability to increase the organism’s resistance to the various extreme factors action, such as stresses, conflict situations, electric shock, physical activity, hypoxia, sleep deprivation, various intoxications. Along with this, bK-IMP eliminates abnormalities arising from alcoholism and drug addiction. If you’re looking for the best place to buy bK-IMP drug online, visit RC’s online store to place an order.

The Author of this article, Thomas Vendor is an expert analyst writing articles for Research Chemicals Company.



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